Akihiko Kawahara Selected Research

N- (pyridine- 3- ylmethyl)- 5- (7- hydroxy- 2,6,8- trimethyl- 1,2,4a,5,6,7,8,8a- octahydronaphthalene- 1- yl)- 2- methylpenta- 2,4- dienamide

7/2012

The antitumor effect of a novel angiogenesis inhibitor (an octahydronaphthalene derivative) targeting both VEGF receptor and NF-κB pathway.

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Akihiko Kawahara Research Topics

Disease

83	Neoplasms (Cancer) 01/2022 - 11/2003
35	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 06/2009
15	Lung Neoplasms (Lung Cancer) 01/2022 - 09/2009
9	Neoplasm Metastasis (Metastasis) 01/2022 - 12/2008
9	Breast Neoplasms (Breast Cancer) 01/2020 - 03/2008
8	Colorectal Neoplasms (Colorectal Cancer) 12/2019 - 07/2011
7	Carcinoma (Carcinomatosis) 01/2022 - 11/2014
5	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2021 - 04/2012
5	Stomach Neoplasms (Stomach Cancer) 07/2020 - 08/2010
5	Adenocarcinoma of Lung 06/2019 - 02/2014
4	Adenocarcinoma 05/2021 - 07/2011
3	Squamous Cell Carcinoma of Head and Neck 12/2020 - 01/2020
3	Pleural Effusion (Pleural Effusions) 09/2019 - 02/2014
3	Insulinoma 09/2019 - 03/2018
3	Pancreatic Neoplasms (Pancreatic Cancer) 10/2016 - 06/2006
2	Esophageal Squamous Cell Carcinoma 08/2021 - 10/2016
2	Triple Negative Breast Neoplasms 01/2020 - 07/2014
2	Renal Cell Carcinoma (Grawitz Tumor) 11/2018 - 08/2015
2	Neuroendocrine Tumors (Neuroendocrine Tumor) 05/2018 - 03/2018
2	Melanoma (Melanoma, Malignant) 11/2017 - 06/2009
2	Lymphatic Metastasis 01/2014 - 05/2012
2	Carcinogenesis 06/2012 - 07/2011
2	Papillary Thyroid Cancer 10/2011 - 08/2011
1	Oropharyngeal Neoplasms 01/2021
1	Head and Neck Neoplasms (Head and Neck Cancer) 01/2020

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2006
15	ErbB Receptors (EGF Receptor)IBA 09/2017 - 09/2009
13	Biomarkers (Surrogate Marker)IBA 01/2021 - 09/2009
9	LigandsIBA 01/2021 - 03/2015
9	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 04/2011
8	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 06/2009
8	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 08/2018 - 08/2011
8	Peptides (Polypeptides)IBA 05/2016 - 04/2012
7	Immune Checkpoint InhibitorsIBA 01/2022 - 11/2017
7	B7-H1 AntigenIBA 01/2021 - 01/2017
7	Fluorine-18IBA 01/2020 - 07/2010
7	DNA (Deoxyribonucleic Acid)IBA 09/2018 - 06/2010
7	Gefitinib (Iressa)FDA Link 01/2014 - 06/2010
6	Erlotinib Hydrochloride (CP 358,774)FDA Link 09/2017 - 06/2010
5	Biological ProductsIBA 10/2016 - 07/2013
5	AntibodiesIBA 11/2014 - 06/2010
4	Pharmaceutical PreparationsIBA 01/2022 - 07/2012
4	SynaptophysinIBA 09/2019 - 08/2012
4	Transcription Factors (Transcription Factor)IBA 01/2017 - 02/2013
4	Monoclonal AntibodiesIBA 10/2016 - 11/2014
4	MucinsIBA 11/2014 - 04/2012
4	Phosphotransferases (Kinase)IBA 08/2014 - 06/2009
3	Carboplatin (JM8)FDA LinkGeneric 01/2021 - 06/2009
3	Anaplastic Lymphoma KinaseIBA 09/2018 - 11/2014
3	VimentinIBA 02/2018 - 11/2003
3	ChromatinIBA 02/2018 - 07/2008
3	Cadherins (E-Cadherin)IBA 02/2018 - 06/2012
3	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 10/2014 - 07/2010
3	matrigelIBA 01/2014 - 06/2006
3	Tyrosine Kinase InhibitorsIBA 01/2014 - 01/2012
3	CateninsIBA 07/2012 - 07/2011
2	osimertinibIBA 01/2022 - 09/2017
2	PlatinumIBA 01/2021 - 01/2013
2	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2020 - 01/2017
2	Cell-Free Nucleic AcidsIBA 01/2019 - 10/2015
2	Keratins (Keratin)IBA 05/2018 - 04/2018
2	Estrogen Receptor alphaIBA 01/2018 - 03/2008
2	HLA Antigens (Human Leukocyte Antigens)IBA 11/2017 - 10/2013
2	AfatinibIBA 09/2017 - 08/2014
2	Cancer VaccinesIBA 05/2016 - 10/2013
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 10/2015 - 05/2015
2	Phenobarbital (Luminal)FDA Link 07/2015 - 11/2002
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2014 - 06/2009
2	Docetaxel (Taxotere)FDA Link 11/2013 - 08/2009
2	CytokinesIBA 08/2013 - 04/2011
2	Indicators and Reagents (Reagents)IBA 04/2013 - 05/2012
2	Insulin (Novolin)FDA Link 02/2013 - 07/2011
2	locked nucleic acidIBA 01/2013 - 10/2011
2	Peptide Nucleic AcidsIBA 01/2013 - 10/2011
2	EnzymesIBA 06/2012 - 08/2010
2	Claudin-1IBA 06/2012 - 07/2011
2	Small Interfering RNA (siRNA)IBA 05/2012 - 03/2008
2	TubulinIBA 08/2009 - 06/2009
1	Amino Acids FDA Link 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Tryptophan (L-Tryptophan)FDA Link 01/2022
1	entrectinibIBA 01/2022
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 08/2021
1	Messenger RNA (mRNA)IBA 05/2021
1	Etoposide (VP 16)FDA LinkGeneric 01/2021
1	atezolizumabIBA 01/2021
1	Adapalene (Differin)FDA LinkGeneric 07/2020
1	Adenosine Monophosphate (AMP)IBA 01/2020
1	Adenosine (Adenocard)FDA LinkGeneric 01/2020
1	NivolumabIBA 01/2020
1	Carrier Proteins (Binding Protein)IBA 01/2020
1	Therapeutic UsesIBA 06/2019

Therapy/Procedure

12	Therapeutics 12/2020 - 08/2009
9	Drug Therapy (Chemotherapy) 01/2021 - 06/2009
7	Immunotherapy 08/2021 - 04/2012
3	Radiotherapy 12/2020 - 05/2012
3	Aftercare (After-Treatment) 01/2019 - 10/2015
2	Chemoradiotherapy 01/2021 - 03/2016
2	Gastrectomy 07/2020 - 04/2013
2	Neoadjuvant Therapy 11/2017 - 11/2013